Open Access Open Access  Restricted Access Subscription Access
Cover Image

Role of nucleotides supplementation in reduce rate of pulmonary hypertension syndrome in broiler chickens

mohammad safaei, Ahmad Hassanabadi, Mojtaba Tahmoorespur

Abstract


ABSTRACT:

Background: Ascites is a major cause of mortality and morbidity in modern broiler production. The aim of this study was to determine the effects of different levels of dietary Nucleotide Supplementation (NS) on pulmonary hypertension syndrome (also known as ascites syndrome, AS).

Materials and methods: In the trial, 308 Ross 308 (mixed sex) broiler chickens were distributed in a completely randomized experimental design into 4 treatments with 7 replicates of 11 birds each. Experimental groups were defined by the inclusion of 0 (control), 0.5, 1 and 2 g/kg NS in the diets. Ascites was induced in broiler chickens by excess salt (receiving 0.2 % NaCl) in drinking water. Growth performance, mortality, blood parameters as well as ascites indices (right ventricle [RV], total ventricle [TV] weights, and RV/TV) were evaluated.

Results: The results of this study showed that feed intake, body weight gain, feed conversion ratio of broilers were not affected by treatments (P> 0.05). Ascites-related mortality, plasma triiodothyronine (T3) concentrations were significantly decreased in treatment with 1 g/Kg nucleotide in diets (P<0.05). RV weight was significantly heavier and RV/TV ratios was significantly higher in treatment with 0 g/Kg nucleotide diets, and decreased in treatment with 1 g/Kg nucleotide in diets (P<0.05).

Conclusion: Our findings showed that excess salt in drinking water induced pulmonary hypertension in broiler chickens. It is concluded that the inclusion of 1 g/kg nucleotide in susceptible broiler chicken diets has a systemic anti-hypertensive effect and could decrease ascites incidence.


Keywords


ascites, broiler, nucleotide, excess salt

Full Text:

PDF

References


REFERENCES

Arce-Menocal, J., Avila-Gonzalez, E., Lopez-Coello, C., Garibaytorres, L., & Martinez-Lemus, L.A. (2009). Body Weight Feed-Particle Size, And Ascites Incidence Revisited. Journal of Applied Poultry Research, 18, 465–471.

Banaee, M., Mirvagefei, A.R, Rafei, G.R., & Majazi Amiri, B. (2008). effect of sub-lethal diazinon concentrations on blood plasma biochemistry, International Journal Environmental Research, 22, 189-198.

Carver, J.D., & Walker, V.A.(1995). The role of nucleotides in human nutrition. Nutritional Biochemistry, 6, 58-72.

Daneshyar, M., Kermanshahi, H., Golian, A. (2009). Changes of biochemical parameters and enzyme activities in broiler chickens with cold-induced ascites. Poultry Science, 88, 106–110.

Gupta, A.R. (2011). Ascites syndrome in poultry: a review. World Poultry Science Journal, 67, 457–467.

Julian, R.J. (2005). Production and growth related disorders and other metabolic disease of poultry- a review. Veterinary Journal,169, 350–369.

Jung, B., & Batal, A.B. (2012). Effect of dietary nucleotide supplementation on performance and development of the gastrointestinal tract of broilers. British Poultry Science, 53, 98-105.

Kamely, M., Karimi Torshizi, M.A., & Rahimi, S. (2015). Incidence of ascites syndrome and related hematological response in short-term feed-restricted broilers raised at low ambient temperature. Poultry Science, 94, 2247–2256.

Mirsalimi, S.M., & Julian, R.J. (1993). Saline drinking water in broiler and leghorn chicks and the effect in broilers of increasing levels and age at time of exposure. Canadian Veterinary Journal, 34, 413–417.

National Research Council. Nutrient requirements of poultry, 9th rev. ed. National Academy Press, Washington, DC. 1994.

Naughton, M.l., Bentley, D., Koeppel, P. (2007). The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. The Journal of Sports Medicine, 47, 112-118.

Pelícia, V.C., & Sartori, J.R. (2010). Effect of nucleotides on broiler performance and carcass yield. Brazilian Journal of Poultry Science, 12, 31-34.

Quinn, C.T., Smith, E.P., Arbabi, S., Khera, P.K., Lindsell, C.J., Niss, O., Joiner, C.H., Franco, R.S,, Cohen, R.M. (2016). Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia. American Journal of Hematology, 91(12), 1195-1201.

Sas Institute.(2005). Sas User’s Guide: Statistics. Version 9.1.3 ed. (Sas Institute Inc, Cary, Nc).

Scheele, C.W., Van Der Klis, J., Kwakernaak, C., Buys, N., & Decuypere, E. (2003). Hematological characteristics predicting susceptibility for ascites. 2. High hematocrit values in juvenile chickens. British poultry science, 44, 484–489.

Szabo, A., Mezes, M., Horn, P., Suto, Z., Bazar, G., & Romvari, R. (2005). Developmental dynamics of some blood biochemical parameters in the growing turkey (Meleagris Gallopavo). Acta Veterinary Hungary, 53 (4), 397-409.

Vasquez-Garibay, E., Stein, K., Kratzsch, J., Romero, V., & Jahreis, J. (2006). Effect of nucleotide intake and nutritional recovery on insulin-like growth factor I and other hormonal biomarkers in severely malnourished children. British Journal of Nutrition, 96 (4), 683-690.

Wang, Y., Guo, Y., Ning, D., Peng, Y., Cai, H., Tan, J., Yang, Y., & Liu, D. (2012). Changes of hepatic biochemical parameters and proteomics in broilers with cold-induced ascites. Journal of Animal Science and Biotechnology, 3, 41-49.

Wideman, R.F,, Rhoads, D.D,, Erf, G.F., & Anthony, N.B. (2013). Pulmonary arterial hypertension (ascites syndrome) in broilers: a review. Poultry Science, 92, 64–83.

Yahav, S., Goldfeld, S., Plavnik, I., & Hurwitz, S.(1995). Physiological responses of chickens and turkeys to relative humidity during exposure to high ambient temperature. Journal of Thermal Biology, 20, 245–253.

Zavarize, K.C., Sartori, J.R., Pelícia, V.C., Pezzato, A.C., & Araujo, P.C. (2007). Desempenho de frangos de corte criados no sistema alternative suplementados com L-glutamina e nucleotídeos. Anais da Conferência PINCO 2007 de Ciência e Tecnologia Avícolas; Santos; São Paulo. Brasil. Campinas: FACTA, 109-113.

Zhang, J., Feng, X., Zhao, L., Wang, W., Gao, M., Wu, B., & Qiao, J.(2013). Expression of hypoxia-inducible factor 1α mRNA in hearts and lungs of broiler chickens with ascites syndrome induced by excess salt in drinking water. Poultry Science, 92, 2044–2052.


Refbacks

  • There are currently no refbacks.