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Deepithelization of fingers and palm.

Clinical analysis of 55 cases of Kawasaki disease and the use of IVIG for Coronary Artery Lesion

Yong Lin Liu, Jun Feng Ma, Bilal Haider Shamsi

Abstract


Objective: To investigate Kawasaki disease (KD) and clinical features of associated coronary artery damage. Methods 55 cases of KD treated at Shenmu hospital from August 1999 to January 2016 were retrospectively analyzed and studied. Results 55 cases of KD had 39 males and 16 females, male to female ratio was 2.44: 1, the youngest case was 2 months old while oldest case was 8 years and 10 months old, <1 year of age group had 18 cases, 1 to 3 years old had 17 cases, 3 to 5 years had 10 cases > 5 years had 10 cases, with an average age of 4 years and 10 months. Amongst all, 47 cases were typical while 8 cases were atypical. Coronary artery lesions were observed in 14 cases, 12 cases had coronary artery ectasia, 2 cases developed coronary artery aneurysms while 2 cases developed pericardial effusion. Follow up was performed after 6 months to 2 years of treatment. Coronary artery damage recovered after 12 months of the treatment. 1 case was reported of recurrence after1 year. Conclusions The incidence of coronary artery lesion was 39.3%. late treatment resulted in atypical cases and delayed application of gamma globulin resulted in delayed healing. IVIG 2g / (kg · d) single dose intravenous application within 10 days resulted in better prevention of coronary artery lesion and fever control. Atypical cases should be noted very carefully for scar redness, perianal skin peeling, and significant rise in ESR and CRP values.


Keywords


Kawasaki disease; Atypical; coronary artery lesion; gamma globulin.

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References


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