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Clinical analysis of 55 cases of Kawasaki disease and the use of IVIG for Coronary Artery Lesion

Yong Lin Liu, Jun Feng Ma, Bilal Haider Shamsi


Objective: To investigate Kawasaki disease (KD) and clinical features of associated coronary artery damage. Methods 55 cases of KD treated at Shenmu hospital from August 1999 to January 2016 were retrospectively analyzed and studied. Results 55 cases of KD had 39 males and 16 females, male to female ratio was 2.44: 1, the youngest case was 2 months old while oldest case was 8 years and 10 months old, <1 year of age group had 18 cases, 1 to 3 years old had 17 cases, 3 to 5 years had 10 cases > 5 years had 10 cases, with an average age of 4 years and 10 months. Amongst all, 47 cases were typical while 8 cases were atypical. Coronary artery lesions were observed in 14 cases, 12 cases had coronary artery ectasia, 2 cases developed coronary artery aneurysms while 2 cases developed pericardial effusion. Follow up was performed after 6 months to 2 years of treatment. Coronary artery damage recovered after 12 months of the treatment. 1 case was reported of recurrence after1 year. Conclusions The incidence of coronary artery lesion was 39.3%. late treatment resulted in atypical cases and delayed application of gamma globulin resulted in delayed healing. IVIG 2g / (kg · d) single dose intravenous application within 10 days resulted in better prevention of coronary artery lesion and fever control. Atypical cases should be noted very carefully for scar redness, perianal skin peeling, and significant rise in ESR and CRP values.


Kawasaki disease; Atypical; coronary artery lesion; gamma globulin.

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Kuo, H.C., et al., Identification of an association between genomic hypomethylation of FCGR2A and susceptibility to Kawasaki disease and intravenous immunoglobulin resistance by DNA methylation array. Arthritis & Rheumatology, 2015. 67(3): p. 828-836.

Kuo, H.-C., et al., High-dose aspirin is associated with anemia and does not confer benefit to disease outcomes in kawasaki disease. PloS one, 2015. 10(12): p. e0144603.

Uehara, R. and E.D. Belay, Epidemiology of kawasaki disease in Asia, Europe, and the United States. Journal of Epidemiology, 2012. 22(2): p. 79-85.

Williams, K., Preventing Long-Term Cardiac Damage in Pediatric Patients With Kawasaki Disease. Journal of Pediatric Health Care, 2016.

Ayusawa, M., et al., Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition). Pediatr Int, 2005. 47(2): p. 232-4.

Ueda, Y., et al., adult-onset Kawasaki disease (mucocutaneous lymph node syndrome) and concurrent Coxsackievirus a4 infection: a case report. International medical case reports journal, 2015. 8: p. 225.

Stagi, S., et al., Kawasaki disease (strawberry tongue) associated with very low vitamin D–May 2015. Clinical Rheumatology, 2015.

Jiao, F., X. Yan, and X. Wu, The Xi’an Experience of Kawasaki Disease–Lessons Learnt over 5 years. The Indian Journal of Pediatrics, 2016: p. 1-2.

Tseng, H.C., et al., Bull's eye dermatoscopy pattern at bacillus Calmette–Guérin inoculation site correlates with systemic involvements in patients with Kawasaki disease. The Journal of dermatology, 2016.

Zhou, C., et al., Abstract O. 07: The Clinical Risk Factors of Intravenous Immunoglobulin Resistance and Coronary Artery Lesion of Kawasaki Disease: Retrospective Analysis of 602 Cases. Circulation, 2015. 131(Suppl 2): p. AO07-AO07.

Zhu, H., et al., Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years. Experimental and therapeutic medicine, 2015. 10(1): p. 357-361.

Ko, T.-M., et al., CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. Circulation research, 2015. 116(5): p. 876-883.

Ko, T.-M., et al., Abstract O. 30: Novel Biomarker for Early Diagnosis of Kawasaki Diseases. Circulation, 2015. 131(Suppl 2): p. AO30-AO30.

Kuo, H.-C., et al., Kawasaki disease: an update on diagnosis and treatment. Pediatrics & Neonatology, 2012. 53(1): p. 4-11.

Khoury, M., et al., Magnetic Resonance Imaging in Children with Cardiac Complications of Kawasaki Disease: a Comparison with Echocardiography and Conventional Coronary Angiography. Circulation, 2015. 131(Suppl 2): p. A220-A220.

Eleftheriou, D., et al., Management of Kawasaki disease. Archives of disease in childhood, 2014. 99(1): p. 74-83.

Kim, H.-J., et al., Assessment of Therapeutic Effect of Medium-Dose Intravenous Immunoglobulin as An Initial Treatment for Kawasaki Disease in Korean Children. Circulation, 2015. 131(Suppl 2): p. A133-A133.

Kazatchkine, M.D. and A. Louwagie, Immunoglobulins: Extending the Horizon. 1994: Taylor & Francis.

Ye, Q., et al., A comprehensive assessment of the value of laboratory indices in diagnosing Kawasaki dis


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