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Antimicrobial and Biocompatible Bacterial Cellulose as Wound Dressing

ÇobanE. P, Şahin S, Bıyık H. H, Özmen I, Ünsal H, Bengül E

Abstract


Background:Bacterial cellulose is an alternative to plant cellulose and is appropriate for many biomedical applications.

Materials and methods: In this study acetic acid bacteria was isolated and identified as Gluconacetobacter hansenii from vinegar samples for bacterial cellulose production. Morphology of cellulose was characterized by SEM and FTIR. Swelling ratio, moisture content and water retention capacity of purified cellulose were determined. Antimicrobial activity of dried bacterial cellulose films impregnated with benzalkonium chloride in different concentrations (0.015%, 0.025%, 0.050%, 0.1%) were tested against some Gram (+), Gram (-) bacteria and some yeasts.The biocompatible of pure bacterial cellulose was examined in an animal model.

Results: Results showed that swelling ratio, moisture content and water retention capacity of purified bacterial cellulose were determined as 60%, 29%and 96%, respectively. Although pure bacterial cellulose films have no antimicrobial effect, they were given antimicrobial properties using benzalkonium chloride solution in different concentrations. Benzalkonium chloride containing bacterial cellulose dry films showed higher antimicrobial effects especially against Gram (+) bacteria such as S. epidermidis ATCC 12228, B.  cereus ATCC 11778, M. luteus, ATCC 9341, S. aureus ATCC 25923. Bacterial cellulose showedno irritation on skin.

Conclusion: We have found that bacterial cellulose has a biocompatibility and could provide antimicrobial properties as biomaterial. Therefore bacterial cellulose dry films could be used as an antimicrobial wound dressing for trauma treatment on the wound area in the medical field. 


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