Open Access Open Access  Restricted Access Subscription Access
Cover Image

DIAGNOSTIC OF CANCERS BY FE3O4 COATED WITH POLYETHYLENE GLYCOL AND FOLIC ACID

A. KHORRAMDOUST, M. ASHOOR, K. SABERYAN, A. EIDI

Abstract


The aim of this study was to introduce modified magnetite nanoparticles (NPs) that have a potential performance to specifically target tumor tissues leaving healthy cells intact. In this study, we have synthesized Fe3O4 nanoparticles coated with the polyethylene glycol (PEG) and folic acid (FA-PEG-Fe3O4) as magnetic resonance contrast agent. These NPs, in the first stage and in the presence of PEG, were prepared by coprecipitation method. In the next stage the folic acid was coated on the PEG-Fe3O4. The structure of FA-PEG-Fe3O4 was characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy and vibrating sample magnetometry. The FA-PEG-Fe3O4 NPs had cubic shapes with sizes of about 9 and 12 nm for PEG-Fe3O4 and FA-PEG-Fe3O4, respectively. These NPs exhibited superparamagnetic behavior with a saturation magnetization of about23 emu/g at room temperature. The 1/T2 relaxivity in case of FA-PEG-Fe3O4, r2 value (305.5 mM-1 s-1) The FA-PEG-Fe3O4 NPs can specially lo­calize in the tumor and produced a suitable contrast in MRI maps. Therefore, one can conclude it is a good candidate for using as a contrast agent in macrophage cells imaging with MRI. These NPs may be employed to early detection of cancer.


Full Text:

PDF

Refbacks

  • There are currently no refbacks.