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In Silico Predictions of Reproductive Toxicity and Histopathological Changes in Rats Testes after chronic Exposures to Pyrimethanil

Perica Vasiljević, Margareta Nikolić, Milena Aleksić, Andrea Žabar Popović, Marina Jušković


Background: The pyrimethanil is a fungicide extensively used in agriculture. The aim of this study was to predict the reproductive toxicity of pyrimethanil and its potential for the induction of histopathological changes in rat testes.

Materials and methods: In silico methods (CAESAR and PG) have been used for predicting the reproductive toxicity of pyrimethanil. In vivo study was designed to analyze the effects of six different concentrations (500, 600, 700, 800, 900 and 1000 mg/kg body weight) of pyrimethanil on adult male rats. The following were observed: the testis weight, testicular histomorphology and sperm count and motility.

Results: CAESAR model classifies pyrimethanil as toxic while PG model as non-toxic. In vivo study shows a significant decrease in testis weight, sperm count and motility and changes in testicular histomorphology at the higher doses of pyrimethanil.

Conclusion: We can conclude that the results show that chronic exposure to pyrimethanil can cause reduced reproductive (spermatogenic) capacity in males.

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