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Impact of Prescribed Multiple Tablet Dosage Forms On the Disintegration Time of Tablets and Physicochemical Parameters of Disintegration Medium

Syed Zia Husnain, Nadeem Irfan Bukhari, Khalid Hussain, Zikria Saleem

Abstract


Aim: This study evaluates effect of prescribed multiple tablets on their in-vitro disintegration time and pH and viscosity of disintegration medium when given individually and in prescribed combinations.

Material & Methods: Prescriptions having only tablet dosage forms were selected. Disintegration time of prescribed combinations was evaluated at three conditions. In Condition 1, prescribed tablets were taken individually in separate disintegration medium, In Condition 2, all tablet formulations prescribed on single prescription were placed at once in medium and in Condition 3, all prescribed tablet formulations on one prescription was placed one after another with 10 min interval. The disintegration time was noted for tablets in all the above conditions, while viscosity and pH of disintegration media were evaluated at Condition 1 and 2. The data of pH and viscosity of two tablet (C2) and that of three or more tablets (C≥ 3) were compared to data of all combinations (data of C2+ C≥ 3) and labeled as CT. Degree of unionized drug was computed for prescribe combination with significant change in pH in Condition 1 and 2. Data were statistically analyzed using SPSS.

Results: Disintegration times of studied tablets at all conditions did not differed (p≥0.05). However, combination of two tablets shown significant change in pH of respective disintegration media (p<0.05), while viscosity of disintegration media for C2, C≥ 3 and CT at Condition 1 and 2 and pH for C≥ 3 and CT at the above two conditions did not varied. Fraction unionized of drug in combination of C2 in Condition 1 and 2 also varied with changed pH of the disintegration media.

Conclusion: Prescribed drug combinations affect physicochemical parameters of in-vitro disintegration fluids, which may affect the bioavailability and therapeutic outcome.


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