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PH Assessment of Sinonasal Secretions in Patients with and without Rhinosinsitis

MohammadHossein Dadgarnia, Hossein Mahmoudi, MohammadHossein Baradaranfar, Sedighe Vaziribozorg, Vahid Zand


  • Aim: This study attempted to determine the means of pH in nasal and sinus secretions in patients with clinical rhinosinusitis and normal healthy subjects, and compare them in order to offer further studies to explore a spray or drip with resetting pH capacity.
  • Materials and Methods: This observational descriptive study was conducted on patients diagnosed with rhinosinusitis based on the criteria described by the Rhinosinusitis Task Force of the American Academy of Otolaryngology-Head and Neck Surgery. Fifty cases clinically diagnosed with rhinosinusitis and 50 normal subjects who were homogenous in terms of sex and gender were evaluated in the current study. During anterior rhinoscopy, PH meter probe was advanced into the middle meatus to measure and record mucosa or secretions pH.
  • Results: The mean age of patients was 43.52 in the control group and 41.86 in the case group (P value = 0.545). Considering sex, 64% were female and 36% male in the control group, and 58% were female and 42% male in the case group (P. value = 0.535). Mean nasal pH measured in the middle meatus was 6.42 in the control group (minimum: 4.92 maximum: 8.16) and 6.84 in the case group (minimum: 5.13 maximum: 8.19) which reflected a statistically significant difference (P .value = 0.008). In other words, mean nasal pH was more acidic in normal subjects compared to rhinosinusitis cases.
  • Conclusion: PH of nasal and sinus secretions in patients with rhinosinusitis showed a trend toward alkalinity compared to healthy subjects.


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