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A Cohort Study of Simple Noninvasive Parameters Reflecting Fibrosis and Cirrhosis in Chronic HCV Patients

Abdur Rahim, Mukhtiar Hassan, Ghosia Luthfullah, Zia Ur Rahman Awan, Hayat Khan

Abstract


Hepatic cirrhosis is a life threatening disease arising from different chronic liver disorders. Noninvasive procedure such as Serum biochemical markers with high sensitivity and specificity are needed to assess the severity of hepatic fibrosis and cirrhosis.This study aimed to differentiate serum biochemical markers in various stages of liver fibrosis and cirrhosis based on fibroscan findings. In a retrospective study, 04 group of patients with no fibrosis(F0), minimal fibrosis having no cirrhosis(F1), severe fibrosis (F2-F3) and cirrhosis (F4) were investigated for serum biochemical markers, comprising 449 patients with histological complications.The level of statistical significance was set at P < 0.05.Results of this study showed that in patient group with severe fibrosis (F2-F3), ALT, AST, GGT, ALP, AST/ALT, GGT/ALT, T. Bilirubin and DDimer were  highly elevated than upper normal limit as compared to patient group with no fibrosis (F0) and were found statistically significant (P<0.05). ALB, haptoglobin and platelet were lower than lower normal limit  in patient group with severe fibrosis (F2-F3) as compared to patient group with no fibrosis (F0)  and were found statistically significant (P<0.05).Patients group with cirrhosis (F4), has highly elevated AST, ALP, AST/ALT, GGT/ALT, T. Bilirubin and D-dimer than upper normal limit as compared to patients group with no cirrhosis (F1) and were  statistically significant (P<0.05).  Whereas ALB, haptoglobin and platelet count were lower than lower normal limit in patients with cirrhosis (F4) as compared with no cirrhosis (F1) group. These results were also found statistically significant (P<0.05).


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